Sickle Cell Disease

Sickle cell disease is a genetic blood disorder where the red blood cell are misshapen. The disease is an autosomal recessive genetic disorder. The main effect is anemia due to low red blood cell counts, resulting from chronic hemolytic anemia. The most common early symptoms are the symptoms of anemia ...

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Introduction: Sickle Cell Disease

SCD is a group of inherited red blood cell disorders. Healthy red blood cells are round, and they move through small blood vessels to carry oxygen to all parts of the body. In someone who has SCD, the red blood ...1

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Symptoms of Sickle Cell Disease

The number of red blood cells is usually lower than normal. This condition, called anemia, can make a person have less energy. The lack of tissue oxygen can cause attacks of sudden, severe pain, called pain crises. These pain attacks ...2

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Complications of Sickle Cell Disease

Major Complications of Sickle Cell Disease: Acute Pain (Sickle Cell or Vaso-occlusive) Crisis Pain episodes (crises) can occur without warning when sickle cells block blood flow and decrease oxygen delivery. People describe this pain as sharp, intense, stabbing, or ...3

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Causes of Sickle Cell Disease

Sickle cell anemia is a serious, inherited disease. In this disease, the body makes abnormal hemoglobin. This causes the red blood cells to have a sickle, or crescent, shape. Sickle cells don't last as long as healthy red blood cells ...4

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Causes List for Sickle Cell Disease

Some possible causes of Sickle Cell Disease or similar disorders may include:5

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Types of Sickle Cell Disease

When a person has two hemoglobin S genes, Hemoglobin SS, the disease is called sickle cell anemia. This is the most common and often most severe kind of SCD. Hemoglobin SC disease and hemoglobin S? thalassemia (thal-uh-SEE-me ...6

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Diagnosis of Sickle Cell Disease

How Is Sickle Cell Disease Diagnosed? Screening Tests People who do not know whether they make sickle hemoglobin (hemoglobin S) or another abnormal hemoglobin (such as C, ? thalassemia, E) can find out by having their blood tested. This way, they ...7

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Genetics of Sickle Cell Disease

Hemoglobinopathies include sickle cell disease and thalassemias. These are recessive genetic disorders. This means that the disease occurs when a person inherits an abnormal gene from both parents. If both parents carry a hemoglobinopathy gene, there is a 25 percent ...8

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Risk Factors for Sickle Cell Disease

Who Is at Risk for Sickle Cell Disease? In the United States, most people with sickle cell disease (SCD) are of African ancestry or identify themselves as black.

  • About 1 in 13 African American babies is born with sickle cell ...
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Treatments: Sickle Cell Disease

At the present time, hematopoietic stem cell transplantation (HSCT) is the only cure for SCD. Unfortunately, most people with SCD are either too old for a transplant or donít have a relative who is a good enough genetic match ...9

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Prevention of Sickle Cell Disease

How Can Sickle Cell Disease Be Prevented? People who do not know whether they carry an abnormal hemoglobin gene can ask their doctor to have their blood tested. Couples who are planning to have children and know that they are ...10

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Research for Sickle Cell Disease

Research for Your Health: The NHLBI is part of the U.S. Department of Health and Human Servicesí National Institutes of Health (NIH)óthe nationís biomedical research agency that makes important scientific discovery to improve health and save lives ...11

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Similar Topic Articles

Names and Terminology

Other Names for Sickle Cell Anemia

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  1. Source: CDC NCBDDD: ncbddd/ sicklecell/ facts.html
  2. Source: NHLBI (NIH): health/ health-topics/ topics/ sca
  3. Source: NHLBI (NIH): health/ health-topics/ topics/ sca/ signs
  4. Source: NHLBI (NIH): health/ health-topics/ topics/ ha/ types
  5. Source: Algorithmically Generated List
  6. Source: NHLBI (NIH): health/ health-topics/ topics/ sca
  7. Source: NHLBI (NIH): health/ health-topics/ topics/ sca/ diagnosis
  8. Source: Healthy People (DHHS): 2020/ topics-objectives/ topic/ blood-disorders-and-blood-safety
  9. Source: NHLBI (NIH): health/ health-topics/ topics/ sca
  10. Source: NHLBI (NIH): health/ health-topics/ topics/ sca/ prevention
  11. Source: NHLBI (NIH): health/ health-topics/ topics/ sca/ research

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