Severe Combined Immunodeficiency

Severe Combined Immunodeficiency (SCID): SCID is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting T, B, and natural killer cells. Infants with SCID appear healthy at birth but ...1

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Symptoms of Severe Combined Immunodeficiency

Symptoms & Diagnosis: Typically, symptoms of SCID occur in infancy and include serious or life-threatening infections, especially viral infections, which result in pneumonia and chronic diarrhea. Candida (yeast) infections of the mouth and diaper area and pneumonia caused by the ...2

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Complications of Severe Combined Immunodeficiency

Studies have shown that gene therapy can be an effective treatment for some types of SCID, including X-linked SCID. However, approximately one-quarter of the children developed leukemia two to five years after treatment. Scientists suspect that the vectors ...3

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Causes of Severe Combined Immunodeficiency

Causes: SCID is caused by defects in different genes involved in the development and function of infection-fighting immune cells. More than a dozen genes have been implicated in SCID, but gene defects are unknown in approximately 15 percent of ...4

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Causes List for Severe Combined Immunodeficiency

Some possible causes of Severe Combined Immunodeficiency or similar disorders may include:5

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Types of Severe Combined Immunodeficiency

More than a dozen genes have been implicated in SCID. ...Source: NIAID (NIH)6 ...

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Diagnosis of Severe Combined Immunodeficiency

The SCID newborn screening test, originally developed at NIH, measures T cell receptor excision circles (TRECs), a byproduct of T-cell development. Because SCID infants have few or no T cells, the absence of TRECs may indicate SCID. To confirm ...7

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Genetics of Severe Combined Immunodeficiency

More than 80 percent of SCID infants do not have a family history of the condition. ...Source: NIAID (NIH)8 ...

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Treatments: Severe Combined Immunodeficiency

Treatment: Hematopoietic (blood-forming) stem cell transplantation is the standard treatment for infants with SCID. Ideally, SCID infants receive stem cells from a sibling who is a close tissue match. ...Source: NIAID (NIH)9 ...

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Research for Severe Combined Immunodeficiency

Why is the study of Severe Combined Immunodeficiency (SCID) a priority for NIAID? SCID is a group of rare genetic disorders that may be chronic, debilitating, and costly. By learning more about these disorders and their effects on the body ...10

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Names and Terminology

Related Diseases: The following diseases are related to Severe combined immunodeficiency. If you have a question about any of these diseases, you can contact GARD ...11

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References

  1. Source: NIAID (NIH): niaid.nih.gov/ topics/ scid/ Pages/ default.aspx
  2. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ severe-combined-immunodeficiency-scid
  3. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ scid-treatment
  4. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ severe-combined-immunodeficiency-scid
  5. Source: Algorithmically Generated List
  6. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ severe-combined-immunodeficiency-scid
  7. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ scid-symptoms-diagnosis
  8. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ severe-combined-immunodeficiency-scid
  9. ibid.
  10. ibid.
  11. Source: GARD (NIH): rarediseases.info.nih.gov/ diseases/ 7628/ severe-combined-immunodeficiency

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