Polygenic disorders

What are complex or multifactorial disorders? Researchers are learning that nearly all conditions and diseases have a genetic component. Some disorders, such as sickle cell disease and cystic fibrosis, are caused by mutations in a single gene. The causes of ...1

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Causes of Polygenic disorders

Influence of the environment Very few health conditions are only caused by genes - most are caused by the combination of genes and environmental factors. Environmental factors include lifestyle factors, such as diet and exercise. Around a dozen or so genes ...2

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Types of Polygenic disorders

Most genetic disorders, however, are "multifactorial inheritance disorders," meaning they are caused by a combination of inherited mutations in multiple genes, often acting together with environmental factors. Examples of such diseases include many commonly-occurring diseases, such as heart disease ...3

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  1. Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ primer/ mutationsanddisorders/ complexdisorders
  2. Source: NHS Choices UK: nhs.uk/ conditions/ genetics/ inheritance/ 
  3. Source: NHGRI (NIH): genome.gov/ 19016930/ faq-about-genetic-disorders/ 

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