What are complex or multifactorial disorders?
Researchers are learning that nearly all conditions and diseases have a genetic component. Some disorders, such as sickle cell disease and cystic fibrosis, are caused by mutations in a single gene. The causes of
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Causes of Polygenic disorders
Influence of the environment
Very few health conditions are only caused by genes - most are caused by the combination of genes and environmental factors. Environmental factors include lifestyle factors, such as diet and exercise.
Around a dozen or so genes
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Types of Polygenic disorders
Most genetic disorders, however, are "multifactorial inheritance disorders," meaning they are caused by a combination of inherited mutations in multiple genes, often acting together with environmental factors. Examples of such diseases include many commonly-occurring diseases, such as heart disease
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- Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ primer/ mutationsanddisorders/ complexdisorders
- Source: NHS Choices UK: nhs.uk/ conditions/ genetics/ inheritance/
- Source: NHGRI (NIH): genome.gov/ 19016930/ faq-about-genetic-disorders/
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Note: This site is for informational purposes only and is not medical advice. See your doctor or other qualified medical professional for all your medical needs.