Causes of Noonan syndrome

Noonan syndrome is caused by changes in one of several autosomal dominant genes. A person who has Noonan syndrome may have inherited an altered (mutated) gene from one of his or her parents, or the gene change may be a new change due to an error carried by the egg or sperm or occurring at conception. Alterations in four genes - PTPN11, SOS1, RAF1 and KRAS - have been identified to date.

Source: NHGRI (NIH)1

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Back to: « Noonan syndrome

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What causes Noonan syndrome?

Noonan syndrome is caused by a fault in one of several genes. At least eight different faulty genes have been linked to the condition so far.

Source: NHS Choices UK2

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Causes

Noonan syndrome is caused by a faulty gene, which is usually inherited from one of the child's parents.

There's no evidence to suggest the genetic fault is caused by environmental factors, such as diet or exposure to radiation.

Source: NHS Choices UK3

Causes List for Noonan syndrome

Some of the possible causes of Noonan syndrome or similar disorders may include:4

... Full Causes List for Noonan syndrome »

Genetics of Noonan syndrome

Is Noonan syndrome inherited? Noonan syndrome is inherited in families in an autosomal dominant pattern. This means that a person who has Noonan syndrome has one copy of an altered gene that causes the disorder. In about one-third to ...5

... More on Genetics »

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References

  1. Source: NHGRI (NIH): genome.gov/ 25521674/ learning-about-noonan-syndrome/ 
  2. Source: NHS Choices UK: nhs.uk/ conditions/ Noonan-syndrome/ 
  3. Source: NHS Choices UK: nhs.uk/ conditions/ noonan-syndrome/ causes/ 
  4. Source: Algorithmically Generated List
  5. Source: NHGRI (NIH): genome.gov/ 25521674/ learning-about-noonan-syndrome/ 

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Note: This site is for informational purposes only and is not medical advice. See your doctor or other qualified medical professional for all your medical needs.