Huntington’s Disease

Huntington's disease (HD) is an inherited disorder that causes degeneration of brain cells, called neurons, in motor control regions of the brain, as well as other areas. Symptoms of the disease, which gets progressively worse, include uncontrolled movements (called chorea) ...1

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Symptoms of Huntington’s Disease

Symptoms begin around age 30 or 40 years and include abnormal and uncontrollable movements called chorea, as well as gait changes and lack of coordination. Huntington’s disease may affect a person’s judgment, memory, and other cognitive functions. As ...2

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Causes of Huntington’s Disease

What Causes Huntington's Disease? HD results from genetically programmed degeneration of nerve cells, called neurons,* in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. Specifically affected are cells of the basal ...3

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Causes List for Huntington’s Disease

Some possible causes of Huntington’s Disease or similar disorders may include:4

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Types of Huntington’s Disease

Adult-onset HD, with its disabling, uncontrolled movements, most often begins in middle age. There are, however, other variations of HD distinguished not just by age at onset but by a distinct array of symptoms. For example, some persons develop ...

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Diagnosis of Huntington’s Disease

How is HD Diagnosed? The great American folk singer and composer Woody Guthrie died on October 3, 1967, after suffering from HD for 13 years. He had been misdiagnosed, considered an alcoholic, and shuttled in and out of mental institutions ...5

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Genetics of Huntington’s Disease

Huntington’s disease. This hereditary disorder is caused by a faulty gene for a protein called huntingtin. Children of people with Huntington’s have a 50 percent chance of having the disorder. ...Source: NIA (NIH)6 ...

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Treatments: Huntington’s Disease

Is There a Treatment for HD? Physicians may prescribe a number of medications to help control emotional and movement problems associated with HD. It is important to remember however, that while medicines may help keep these clinical symptoms under control ...7

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Prevention of Huntington’s Disease

Pre-implantation genetic diagnosis - where eggs are fertilised in a laboratory and tested to make sure they don't have the Huntington's disease gene, before being implanted into the womb ...Source: NHS Choices UK8 ...

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Research for Huntington’s Disease

Until recently, scientists understood very little about HD and could only watch as the disease continued to pass from generation to generation. Families saw the disease destroy their loved ones' ability to feel, think, and move. In the last several ...9

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Names and Terminology

One of its earliest names was chorea,* which, as in "choreography," is the Greek word for dance. The term chorea describes how people affected with ...10

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  1. Source: NINDS (NIH): disorders/ huntington/ huntington.htm
  2. Source: NIA (NIH): alzheimers/ publication/ dementias/ other-conditions-cause-dementia
  3. Source: NINDS (NIH): disorders/ huntington/ detail_huntington.htm
  4. Source: Algorithmically Generated List
  5. Source: NINDS (NIH): disorders/ huntington/ detail_huntington.htm
  6. Source: NIA (NIH): alzheimers/ publication/ dementias/ other-conditions-cause-dementia
  7. Source: NINDS (NIH): disorders/ huntington/ detail_huntington.htm
  8. Source: NHS Choices UK: conditions/ huntingdons-disease/ diagnosis/ 
  9. Source: NINDS (NIH): disorders/ huntington/ detail_huntington.htm
  10. ibid.

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