Hemolytic Uremic Syndrome

Hemolytic uremic syndrome (HUS) is characterized by the acute onset of microangiopathic hemolytic anemia, renal injury, and low platelet count. Thrombotic thrombocytopenic purpura (TTP) also is characterized by these features but can include central nervous system (CNS) involvement and fever ...1

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Symptoms of Hemolytic Uremic Syndrome

Clues that a person is developing HUS include decreased frequency of urination, feeling very tired, and losing pink color in cheeks and inside the lower eyelids. Persons with HUS should be hospitalized because their kidneys may stop working and they ...2

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Complications of Hemolytic Uremic Syndrome

Studies have shown that some children who recover from HUS develop chronic complications, including kidney problems, high blood pressure, and diabetes. ...Source: NIDDK (NIH)3 ...

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Causes of Hemolytic Uremic Syndrome

HUS develops when E. coli bacteria lodged in the digestive tract make toxins that enter the bloodstream. The toxins start to destroy red blood cells, which help the blood to clot, and the lining of the blood vessels. In the ...4

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Causes List for Hemolytic Uremic Syndrome

Some possible causes of Hemolytic Uremic Syndrome or similar disorders may include:5

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Types of Hemolytic Uremic Syndrome

Some types of this condition may include:6 Types of Hemolytic Uremic Syndrome:

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Types of Hemolytic Uremic Syndrome

Types may include:7

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Diagnosis of Hemolytic Uremic Syndrome

Laboratory Criteria for Diagnosis: The following are both present at some time during the illness:

  • Anemia (acute onset) with microangiopathic changes (i.e., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND
  • Renal injury (acute onset) evidenced by ...
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Risk Factors for Hemolytic Uremic Syndrome

Are certain people at a higher risk for infection? Children, the elderly, pregnant women, and persons with weakened immune systems should avoid eating raw sprouts of any kind (including alfalfa, clover, radish, and mung bean sprouts). While HUS cases are ...8

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Treatments: Hemolytic Uremic Syndrome

Seek Immediate Care: Parents or caretakers should seek immediate care for a child experiencing any urgent symptoms, such as

Source: NIDDK (NIH)9 ...

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Prevention of Hemolytic Uremic Syndrome

Antibiotics should not be used to treat this infection. There is no evidence that treatment with antibiotics is helpful, and taking antibiotics may increase the risk of HUS. Antidiarrheal agents like ImodiumŪ may also increase that risk. ...Source: CDC10 ...

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Names and Terminology

Other Names: HUS; Acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells') ...Source: GARD (NIH)11 ...

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References

  1. Source: CDC NNDSS: cdc.gov/ nndss/ conditions/ hemolytic-uremic-syndrome-post-diarrheal/ case-definition/ 1996/ 
  2. Source: CDC Features: cdc.gov/ features/ ecoliinfection/ index.html
  3. Source: NIDDK (NIH): niddk.nih.gov/ health-information/ digestive-diseases/ foodborne-illnesses
  4. ibid.
  5. Source: Algorithmically Generated List
  6. Source: NCI Thesaurus
  7. Source: MeSH (U.S. National Library of Medicine)
  8. Source: EFSA (EC/EU): efsa.europa.eu/ en/ topics/ topic/ shiga-toxin-producing-e-coli-outbreaks
  9. Source: NIDDK (NIH): niddk.nih.gov/ health-information/ kidney-disease/ children/ hemolytic-uremic-syndrome
  10. Source: CDC: cdc.gov/ ecoli/ general/ index.html
  11. Source: GARD (NIH): rarediseases.info.nih.gov/ diseases/ 6588/ hemolytic-uremic-syndrome

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