Dent disease

Dent disease is a chronic kidney disorder that occurs almost exclusively in males. In affected individuals, kidney problems result from damage to structures called proximal tubules. Signs and symptoms of this condition appear in early childhood and worsen over time ...1

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Symptoms of Dent disease

What is the most common symptom for Dent disease? The most common symptoms that patients with Dent disease experience are related to the passage of kidney stones, such as pain or blood in the urine. ...Source: RDCRN (NCATS/NIH)2 ...

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Causes of Dent disease

What causes Dent disease? The most common Dent disease is a defect in two genes. There are two main types of Dent, type 1 and type2. Type 1 is more common, which is caused by a defect in a protein ...3

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Types of Dent disease

Some types of this condition may include:4 Types of Dent disease:

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Diagnosis of Dent disease

How is Dent disease diagnosed? Patients that have kidney stone with proteinuria and hypercalciuria can have a genetic test to confirm which gene is not functioning correctly. ...Source: RDCRN (NCATS/NIH)5 ...

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Genetics of Dent disease

Genetic Changes: Dent disease can result from mutations in the CLCN5 or OCRL gene. Mutations in the CLCN5 gene cause Dent disease 1, which accounts for about 60 percent of all cases of Dent disease . Mutations in the OCRL gene ...6

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Treatments: Dent disease

What is/Is there treatment for Dent disease? There is currently no cure for Dent disease, but there are treatments we can offer. Some medications (diuretics) can be given to lower the calcium in the urine and hopefully reduce the ...7

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Names and Terminology

Other Names for This Condition

  • Dent's disease
  • Dents disease

Source: GHR (NLM/NIH)8 ...

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References

  1. Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ condition/ dent-disease
  2. Source: RDCRN (NCATS/NIH): rarediseasesnetwork.org/ cms/ rksc/ Learn-More/ Disease-Definitions
  3. ibid.
  4. Source: NCI Thesaurus
  5. Source: RDCRN (NCATS/NIH): rarediseasesnetwork.org/ cms/ rksc/ Learn-More/ Disease-Definitions
  6. Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ condition/ dent-disease
  7. Source: RDCRN (NCATS/NIH): rarediseasesnetwork.org/ cms/ rksc/ Learn-More/ Disease-Definitions
  8. Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ condition/ dent-disease

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