Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises ...1

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Symptoms of Charcot-Marie-Tooth Disease

A typical feature includes weakness of the foot and lower leg muscles, which may result in foot drop and a high-stepped gait with frequent tripping or falling. Foot deformities, such as high arches and hammertoes (a condition in which ...2

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Causes of Charcot-Marie-Tooth Disease

CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders caused by mutations in genes that affect the normal function of the peripheral nerves. The peripheral nerves lie outside the brain ...3

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Causes List for Charcot-Marie-Tooth Disease

Some possible causes of Charcot-Marie-Tooth Disease or similar disorders may include:4

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Types of Charcot-Marie-Tooth Disease

What are the types of Charcot-Marie-Tooth disease? There are many forms of CMT disease, including CMT1, CMT2, CMT3, CMT4, and CMTX. CMT1, caused by abnormalities in the myelin sheath, has three main types. CMT1A is an autosomal dominant disease ...5

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Diagnosis of Charcot-Marie-Tooth Disease

How is Charcot-Marie-Tooth disease diagnosed? Diagnosis of CMT begins with a standard medical history, family history, and neurological examination. Individuals will be asked about the nature and duration of their symptoms and whether other family members have the ...6

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Genetics of Charcot-Marie-Tooth Disease

Several genes have been found to play a role in different types of Charcot-Marie-Tooth, a group of disorders that are among the most common forms of inherited peripheral neuropathies. These neuropathies result from mutations in genes responsible for ...7

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Treatments: Charcot-Marie-Tooth Disease

Is there any treatment? There is no cure for CMT, but physical therapy, occupational therapy, braces and other orthopedic devices, and orthopedic surgery can help people cope with the disabling symptoms of the disease. In addition, pain-killing drugs can ...8

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Research for Charcot-Marie-Tooth Disease

What research is being done? The National Institute of Neurological Disorders and Stroke (NINDS) conducts CMT research in its laboratories at the National Institutes of Health (NIH) and also supports CMT research through grants to major medical institutions across the ...9

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Names and Terminology

CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. ...Source: NINDS ...10

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  1. Source: NINDS (NIH): disorders/ charcot_marie_tooth/ charcot_marie_tooth.htm
  2. ibid.
  3. ibid.
  4. Source: Algorithmically Generated List
  5. Source: NINDS (NIH): disorders/ charcot_marie_tooth/ detail_charcot_marie_tooth.htm
  6. ibid.
  7. Source: NINDS (NIH): disorders/ peripheralneuropathy/ detail_peripheralneuropathy.htm
  8. Source: NINDS (NIH): disorders/ charcot_marie_tooth/ charcot_marie_tooth.htm
  9. ibid.
  10. Source: NINDS (NIH): disorders/ charcot_marie_tooth/ detail_charcot_marie_tooth.htm

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