Alexander Disease

Alexander disease is one of a group of neurological conditions known as the leukodystrophies, disorders that are the result of abnormalities in myelin, the “white matter” that protects nerve fibers in the brain. Alexander disease is a progressive and often ...1

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Symptoms of Alexander Disease

The infantile form is the most common type of Alexander disease. It has an onset during the first two years of life. Usually there are both mental and physical developmental delays, followed by the loss of developmental milestones, an abnormal ...2

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Causes of Alexander Disease

Alexander disease is one of a group of neurological conditions known as the leukodystrophies, disorders that are the result of abnormalities in myelin, the “white matter” that protects nerve fibers in the brain. The destruction of white matter is accompanied ...3

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Types of Alexander Disease

The infantile form is the most common type of Alexander disease. The juvenile form of Alexander disease is less common. Adult-onset forms of Alexander disease are less common. ...Source: NINDS (NIH)4 ...

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Genetics of Alexander Disease

Genetic Changes: Mutations in the GFAP gene cause Alexander disease . The GFAP gene provides instructions for making a protein called glial fibrillary acidic protein. Several molecules of this protein bind together to form intermediate filaments, which provide support and strength ...5

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Treatments: Alexander Disease

Is there any treatment? There is no cure for Alexander disease, nor is there a standard course of treatment. Treatment of Alexander disease is symptomatic and supportive. ...Source: NINDS (NIH)6 ...

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Research for Alexander Disease

What research is being done? Recent discoveries show that most individuals (approximately 90 percent) with Alexander disease have a mutation in the gene that makes glial fibrillary acidic protein (GFAP). GFAP is a normal component of the brain, but it ...7

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Names and Terminology

Other Names for This Condition

Source: GHR (NLM/NIH) ...8

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References

  1. Source: NINDS (NIH): ninds.nih.gov/ disorders/ alexander_disease/ alexander_disease.htm
  2. ibid.
  3. ibid.
  4. ibid.
  5. Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ condition/ alexander-disease
  6. Source: NINDS (NIH): ninds.nih.gov/ disorders/ alexander_disease/ alexander_disease.htm
  7. ibid.
  8. Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ condition/ alexander-disease

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