Addison’s Disease

Addison’s Disease is an endocrine disease that results in low adrenal gland hormones. This results in adrenal insufficiency. Symptoms are often mild and barely noticeable and the disease may continue for months or years without diagnosis. Some of the symptoms include tiredness, fatigue, weakness, lethargy, faintness, nausea, vomiting, diarrhea ...

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Introduction: Addison’s Disease

Addison’s disease, the common term for primary adrenal insufficiency, occurs when the adrenal glands are damaged and cannot produce enough of the adrenal hormone cortisol. The adrenal hormone aldosterone may also be lacking. Addison’s disease affects 110 to ...1

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Symptoms of Addison’s Disease

Addison’s Disease Symptoms can vary, depending on what causes the disease. Symptoms typically include3,4:

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Complications of Addison’s Disease

Adrenal Crisis: Sudden, severe worsening of adrenal insufficiency symptoms is called adrenal crisis. If the person has Addison’s disease, this worsening can also be called an Addisonian crisis. In most cases, symptoms of adrenal insufficiency become serious enough that ...2

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Causes of Addison’s Disease

In all cases of Addison’s disease, the adrenal glands do not produce enough of the hormone cortisol. In most cases, the glands also make too little of the hormone aldosterone.8 This is also termed primary adrenal insufficiency. This ...3

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Causes List for Addison’s Disease

Some possible causes of Addison’s Disease or similar disorders may include:4

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Types of Addison’s Disease

Some types of this condition may include:5 Types of Addison’s Disease:

  • Autoimmune Primary Adrenal Insufficiency
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Diagnosis of Addison’s Disease

To diagnose Addison’s disease, a health care provider may administer a blood test to measure cortisol and adrenocorticotropic hormone (ACTH) levels. Then he or she may perform an ACTH stimulation test, an hour-long test during which a synthetic ...6

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Genetics of Addison’s Disease

Genetics: Research has shown that some people with certain genes are more likely to develop autoimmune disorders. It's not clear how these genes lead to Addison's disease and similar conditions, but it does mean your risk of developing Addison's disease ...7

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Treatments: Addison’s Disease

Addison’s disease is treated by replacing the cortisol and/or aldosterone that the body is lacking. People with Addison’s disease take oral medication each day to replace these hormones. They may also need to consume additional salt.5 ...8

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Research for Addison’s Disease

Information about you: If you have Addison's disease, your clinical team will pass information about you on to the National Congenital Anomaly and Rare Diseases Registration Service (NCARDRS). This helps scientists look for better ways to prevent and treat this ...9

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Names and Terminology

Other Names: Addison disease; Adrenal hypoplasia; Hypoadrenocorticism familial; Addison disease; Adrenal hypoplasia; Hypoadrenocorticism familial; Adrenal aplasia; Adrenal gland hypofunction ...Source: GARD (NIH)10 ...

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  1. Source: NIDDK (NIH): health-information/ health-topics/ endocrine/ adrenal-insufficiency-addisons-disease/ Pages/ fact-sheet.aspx
  2. Source: NIDDK (NIH): health-information/ endocrine-diseases/ adrenal-insufficiency-addisons-disease
  3. Source: NICHD (NIH): health/ topics/ adrenalgland/ conditioninfo/ pages/ causes.aspx
  4. Source: Algorithmically Generated List
  5. Source: NCI Thesaurus
  6. Source: NICHD (NIH): health/ topics/ adrenalgland/ conditioninfo/ pages/ causes.aspx
  7. Source: NHS Choices UK: conditions/ addisons-disease/ causes/ 
  8. Source: NICHD (NIH): health/ topics/ adrenalgland/ conditioninfo/ pages/ treatment.aspx
  9. Source: NHS Choices UK: conditions/ Addisons-disease/ 
  10. Source: GARD (NIH): diseases/ 5740/ addisons-disease

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Note: This site is for informational purposes only and is not medical advice. See your doctor or other qualified medical professional for all your medical needs.