Von Willebrand factor

von Willebrand Factor: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in Von Willebrand Diseases is due to the deficiency of this factor.1

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von Willebrand factor (2813 aa, ~309 kDa) is encoded by the human VWF gene. This protein is involved in platelet adhesion and blood coagulation.2

Categories for Von Willebrand factor

Category of von Willebrand Factor:

  • Coagulation Factor
3

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References

  1. Source: MeSH (U.S. National Library of Medicine)
  2. Source: NCI Thesaurus
  3. ibid.
  4. [from HPO]
  5. Source: GTR (NCBI/NIH): ncbi.nlm.nih.gov/ gtr/ conditions/ C0151529/ 

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