Transcription Factor

Transcription Factor A protein that activates gene expression.

Source: RDCRN (NCATS/NIH)1

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Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.2

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Transcription factors are a diverse group of proteins that bind to DNA at specific promoter or enhancer regions. They also bind to DNA-associated proteins to initiate, stimulate, inhibit or terminate transcription. The proteins are often physically associated in a preinitiation complex and contain structural motifs.3

Types

Types may include:4

Types of Transcription Factor:

  • Achaete-Scute Complex-Like-1 Protein
  • Activated RNA Polymerase II Transcription Cofactor-4
  • AF-17 Protein
  • AF-4 Protein
  • AF5Q31 Protein
  • AF-9 Protein
  • Alpha-Globin Transcription Factor CP2
  • A-MYB Protein
  • AP-2 Beta Protein
  • AP-2 Gamma Protein
  • Aryl Hydrocarbon Receptor
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Aryl Hydrocarbon Receptor Nuclear Translocator-2
  • Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 1
  • Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 2
  • AT-Rich Interactive Domain-Containing Protein 5B
  • Autoimmune Regulator
  • Basal Transcription Factor
  • B-Cell Lymphoma-6 Protein
  • Bcl-2-Associated Transcription Factor 1
  • B-MYB Protein
  • Brachyury Protein
  • cAMP Responsive Element Binding Protein
  • Carbohydrate-Responsive Element-Binding Protein
  • Caudal Type Homeobox Transcription Factor-2
  • CCAAT-Enhancer Binding Protein Alpha
  • CCAAT-Enhancer Binding Protein Beta
  • CCAAT Enhancer Binding Protein Epsilon
  • Cellular Nucleic Acid-Binding Protein
  • Checkpoint Suppressor-1 Protein
  • Circadian Locomoter Output Cycles Protein Kaput
  • c-Myb Protein
  • c-MYC Protein
  • Core-Binding Factor Alpha
  • Core-Binding Factor Beta Subunit
  • Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha
  • DNA-Binding Protein Ikaros
  • DNA-Binding Protein SATB1
  • DNA Binding Protein SATB2
  • Doublesex- and Mab-3-Related Transcription Factor 1
  • E2F Transcription Factor-1
  • E74-Like Factor-3
  • Early Growth Response Protein 1
  • Early Growth Response Protein 3
  • Ecotropic Virus Integration-1 Site Protein
  • ELK-1 Protein
  • ELK3 Protein
  • Endothelial PAS Domain-Containing Protein 1
  • Endothelial Transcription Factor GATA-2
  • Eomesodermin Homolog
  • ETS1 Protein
  • ETS2 Protein
  • Ets2 Repressor Factor
  • ETS Domain-Containing Protein Elk-4
  • ETS Homologous Factor
  • Ets-Related Transcription Factor Elf-4
  • ETS Translocation Variant 5
  • Ets Variant Protein-1
  • Ets Variant Protein-4
  • ETV3 Protein
  • FLI1 Transcription Factor
  • Forkhead Box C2
  • Forkhead Box-O1A Protein
  • Forkhead Box-O3A Protein
  • Forkhead Box Protein D3
  • Forkhead Box Protein-G1B Protein
  • Forkhead Box Protein L2
  • Forkhead Box Protein M1
  • Forkhead Box Protein-O4 Protein
  • Forkhead Box Protein O6
  • Forkhead Box Protein P1
  • Forkhead Box Protein P2
  • Forkhead Box Protein P3
  • Forkhead Box Protein Q1
  • FOSB Protein
  • FOSL1 Protein
  • FOSL2 Protein
  • FOS Protein
  • GATA-1
  • GLI2 Protein
  • GLI3 Protein
  • GLI Protein
  • Growth Factor Independence-1B Protein
  • GSC Protein
  • Heart-and Neural Crest Derivatives-Expressed Protein 2
  • Heat Shock Factor Protein 1
  • Hematopoietically-Expressed Homeobox Protein HHEX
  • Hepatic Leukemia Factor
  • Hepatocyte Nuclear Factor 1-Alpha
  • Hepatocyte Nuclear Factor 1-Beta
  • Hepatocyte Nuclear Factor 3-Alpha
  • Hepatocyte Nuclear Factor 3-Beta
  • Hepatocyte Nuclear Factor 3-Gamma
  • HKR3 Protein
  • Homeobox Prospero-Like Protein PROX1
  • Homeobox Protein-A10
  • Homeobox Protein-A9
  • Homeobox Protein Aristaless-Like 4
  • Homeobox Protein ARX
  • Homeobox Protein-C6
  • Homeobox Protein CDX-1
  • Homeobox Protein CDX-4
  • Homeobox Protein Cut-Like 1
  • Homeobox Protein DLX-5
  • Homeobox Protein Engrailed-1
  • Homeobox Protein Engrailed-2
  • Homeobox Protein Hox-A1
  • Homeobox Protein Hox-A11
  • Homeobox Protein Hox-A13
  • Homeobox Protein Hox-A3
  • Homeobox Protein Hox-A7
  • Homeobox Protein Hox-B13
  • Homeobox Protein Hox-B4
  • Homeobox Protein Hox-B6
  • Homeobox Protein Hox-B9
  • Homeobox Protein Hox-C10
  • Homeobox Protein Hox-C11
  • Homeobox Protein Hox-C13
  • Homeobox Protein Hox-C5
  • Homeobox Protein Hox-C9
  • Homeobox Protein Hox-D11
  • Homeobox Protein Hox-D13
  • Homeobox Protein-MEIS1
  • Homeobox Protein Meis2
  • Homeobox Protein MSX-1
  • Homeobox Protein-NK2 Homolog-H
  • Homeobox Protein Nkx-2-5
  • Homeobox Protein-NKX3A
  • Homeobox Protein OTX2
  • Homeobox Protein SIX1
  • Homeobox Protein SIX2
  • Homeobox Protein SIX3
  • Homeobox Protein SIX4
  • Homeobox Protein SIX5
  • Homeobox Protein TGIF1
  • Homeobox Transcription Factor Nanog
  • HOX11 Protein
  • Hypoxia-Inducible Factor-1 Alpha Subunit
  • Interferon Regulatory Factor-1
  • Interferon Regulatory Factor-2
  • Interferon Regulatory Factor-3
  • Interferon Regulatory Factor-4
  • Interferon Regulatory Factor 5
  • Interferon Regulatory Factor 6
  • Interferon Regulatory Factor 7
  • Interferon Regulatory Factor 8
  • Interferon Regulatory Factor-9
  • Intestine-Specific Homeobox
  • JUNB Protein
  • JUND Protein
  • JUN Protein
  • Kreuppel-Like Factor 4
  • Krueppel-Like Factor 1
  • Krueppel-Like Factor 5
  • Krueppel-Like Factor 6
  • Leucine-Zipper-Like Transcriptional Regulator 1
  • LIM Homeobox Protein-1
  • LIM Homeobox Protein-2
  • LIM-Homeobox Protein LHX3
  • LIM-Homeobox Protein Lhx4
  • LIM Homeobox Transcription Factor 1 Beta
  • L-Myc Protein
  • LYL1 Protein
  • Lymphoid Enhancer-Binding Factor 1
  • Lymphoid Nuclear Protein-4
  • MAFG Protein
  • MAF Protein
  • MAX Dimerization Protein-1
  • MAX Gene-Associated Protein
  • MAX Interacting Protein-1
  • Microphthalmia-Associated Transcription Factor
  • Mothers Against Decapentaplegic Homolog 5
  • Motor Neuron and Pancreas Homeobox Protein 1
  • Musculin
  • MYC-Associated Factor-X
  • Myelin Transcription Factor 1-Like Protein
  • Myeloid Leukemia Factor 1
  • Myoblast Determination Protein 1
  • Myocardin
  • Myocyte-Specific Enhancer Factor 2A
  • Myocyte-Specific Enhancer Factor 2B
  • Myocyte-Specific Enhancer Factor 2C
  • Myocyte-Specific Enhancer Factor 2D
  • Myogenin
  • Neurogenic Differentiation Factor 1
  • Neurogenin-1
  • NFE2L2 Protein
  • NF-IA Protein
  • NF-IB Protein
  • NF-IC Protein
  • NF-IX Protein
  • NF-Kappa-B-p65 Protein
  • NFKB1 Gene Product
  • NFKB2 Gene Product
  • N-Myc Protein
  • Nuclear Factor Interleukin-3-Regulated Protein
  • Nuclear Factor of Activated T-Cells 5
  • Nuclear Factor of Activated T-Cells Cytoplasmic 1
  • Nuclear Factor of Activated T-Cells Cytoplasmic 2
  • Nuclear Factor of Activated T-Cells Cytoplasmic 3
  • Nuclear Factor of Activated T-Cells Cytoplasmic 4
  • Nuclear Receptor
  • Nuclear Transcription Factor Y Subunit Alpha
  • Nuclease-Sensitive Element Binding Protein 1
  • Oligodendrocyte Transcription Factor 2 Protein
  • OTF-1
  • OTF-2
  • Paired Box-5 Protein
  • Paired Box Protein Pax-1
  • Paired Box Protein PAX-2
  • Paired Box Protein Pax-3
  • Paired Box Protein Pax-6
  • Paired Box Protein Pax-7
  • Paired Box Protein Pax-8
  • Paired Mesoderm Homeobox Protein 1
  • Paired Mesoderm Homeobox Protein 2B
  • Pancreas-Duodenum Homeobox Protein 1
  • Pituitary Homeobox 2
  • Pleiomorphic Adenoma-Like Protein-1
  • POU Domain Class 3 Transcription Factor 2
  • POU Domain Class 5 Transcription Factor 1 Protein
  • PR-Domain Zinc Finger Protein-1
  • PR Domain Zinc Finger Protein 16
  • PR-Domain Zinc Finger Protein-4
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Pre-B-Cell Leukemia Transcription Factor-3
  • Protein AF-10
  • Protein Atonal Homolog 1
  • Protein FEV
  • PU-1 Transcription Factor
  • Putative POU Domain Class 5 Transcription Factor 1B
  • REL Protein
  • Retinoic Acid-Induced Protein 1
  • Rhombotin-1
  • Runt-Related Transcription Factor 2
  • Runt-Related Transcription Factor 3
  • Sal-Like Protein 2
  • Sal-Like Protein 4
  • SAM Pointed Domain-Containing Ets Transcription Factor
  • SCL Transcription Factor
  • Serum Response Factor
  • Signal Transducer and Activator of Transcription-1
  • Signal Transducer and Activator of Transcription-2
  • Signal Transducer and Activator of Transcription-3
  • Signal Transducer and Activator of Transcription-4
  • Signal Transducer and Activator of Transcription-5A
  • Signal Transducer and Activator of Transcription-5B
  • Signal Transducer and Activator of Transcription-6
  • Single-Minded Homolog 1 Protein
  • SMAD2 Protein
  • SNAI2 Protein
  • Sp1 Transcription Factor
  • TATA-Binding Protein-Associated Phosphoprotein
  • T-Box Brain Protein 1
  • T-Box Transcription Factor TBX1
  • T-Box Transcription Factor TBX21
  • T-Box Transcription Factor TBX3
  • T-Box Transcription Factor TBX4
  • T-Box Transcription Factor TBX5
  • T-Cell Acute Lymphocytic Leukemia-2 Protein
  • T-Cell Leukemia Homeobox Protein 3
  • TCF21 Protein
  • TEL Protein
  • Thyroid Transcription Factor 1
  • TOX High Mobility Group Box Family Member 3
  • TP63 Gene Product
  • TP73 Protein
  • Trans-Acting T-Cell-Specific Transcription Factor GATA-3
  • Transcriptional Repressor CTCFL
  • Transcriptional Repressor Protein YY1
  • Transcription Factor 12
  • Transcription Factor-3
  • Transcription Factor-4
  • Transcription Factor 7
  • Transcription Factor-7-Like-2 Protein
  • Transcription Factor-AP2 Alpha
  • Transcription Factor AP-2-Epsilon
  • Transcription Factor AP-4
  • Transcription Factor COE1
  • Transcription Factor Dp-1
  • Transcription Factor-DP2
  • Transcription Factor E2F2
  • Transcription Factor E2F3
  • Transcription Factor E2F4
  • Transcription Factor E2F6
  • Transcription Factor-E3
  • Transcription Factor EB
  • Transcription Factor GATA-4
  • Transcription Factor GATA-5 Protein
  • Transcription Factor GATA-6
  • Transcription Factor HES-1
  • Transcription Factor HES-2
  • Transcription Factor HES-3
  • Transcription Factor HES-4
  • Transcription Factor HES-5
  • Transcription Factor MafA
  • Transcription Factor MafB
  • Transcription Factor MafK
  • Transcription Factor NF-E2 45 kDa Subunit
  • Transcription Factor RelB
  • Transcription Factor SOX-10
  • Transcription Factor SOX-11
  • Transcription Factor SOX-17
  • Transcription Factor SOX-18
  • Transcription Factor SOX-2 Protein
  • Transcription Factor SOX-3 Protein
  • Transcription Factor SOX-4
  • Transcription Factor SOX-6 Protein
  • Transcription Factor SOX-8
  • Transcription Factor SOX-9 Protein
  • Transcription Factor Sp3
  • Transcription Factor Spi-B
  • Transcription Regulator Protein BACH2
  • Transforming Protein-ERG
  • Tripartite Motif-Containing Protein 29
  • Tripartite Motif Protein-TRIM19
  • Twist Related Protein-1
  • Twist-Related Protein 2
  • Upstream Stimulatory Factor 1
  • Upstream Stimulatory Factor 2
  • WT1 Protein
  • X-Box Binding Protein 1
  • Zinc Finger and BTB Domain Containing Protein 7
  • Zinc Finger E-Box-Binding Homeobox 1
  • Zinc Finger E-Box-Binding Homeobox 2 Protein
  • Zinc Finger Homeobox Protein 3
  • Zinc Finger Protein-145
  • Zinc Finger Protein-151
  • Zinc Finger Protein-217
  • Zinc Finger Protein 281
  • Zinc Finger Protein 350
  • Zinc Finger Protein 384
  • Zinc Finger Protein 395
  • Zinc Finger Protein 423
  • Zinc Finger Protein 42 Homolog
  • Zinc Finger Protein 444
  • Zinc Finger Protein 496
  • Zinc Finger Protein 521
  • Zinc Finger Protein 750
  • Zinc Finger Protein Aiolos
  • Zinc Finger Protein GLIS2
  • Zinc Finger Protein Helios
  • Zinc Finger Protein PLAG1
  • Zinc Finger Protein PLAGL2
  • Zinc Finger Protein SNAI1
  • Zinc Finger Protein ZFPM1
  • Zinc Finger Protein ZFPM2
  • Zinc Finger Protein ZIC 1
  • Zinc Finger Protein ZIC 2
  • Zinc Finger Protein ZIC 3
  • Zinc Finger Protein ZIC 4
  • Zinc Finger Transcription Factor Trps1 Protein

Categories for Transcription Factor

Category of Transcription Factor:

  • Transcription Regulatory Protein
5

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References

  1. Source: RDCRN (NCATS/NIH): rarediseasesnetwork.org/ cms/ bbd/ Learn-More/ Glossary
  2. Source: MeSH (U.S. National Library of Medicine)
  3. Source: NCI Thesaurus
  4. ibid.
  5. ibid.

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