Immunoglobulin

Immunoglobulin. Antibodies (See also Antibody) Produced by the body’s immune system, and attach to foreign substances so the immune system can destroy them. They may attach to bacteria, viruses, fungi, cancer cells, and animal dander. There are 5 major types of antibodies. IgA Antibodies are found on mucosal surfaces such as the GI tract, airway, nose, mouth and in body fluids such as tears and saliva. IgE is the allergy antibody. IgG, IgM, and IgD are the other immunoglobulin types.

Source: RDCRN (NCATS/NIH)1

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Immunoglobulins: Multi-subunit proteins which function in Immunity. They are produced by B Lymphocytes from the Immunoglobulin Genes. They are comprised of two heavy (Immunoglobulin Heavy Chains) and two light chains (Immunoglobulin Light Chains) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-Cell Antigen Receptors) or secreted forms (Antibodies). They are divided by the amino acid sequence of their heavy chains into five classes (Immunoglobulin A; Immunoglobulin D; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M) and various subclasses.2

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Immunoglobulin Therapy: The use of immunoglobulins in the treatment of any disease or disorder.3

Types

Types may include:4

Types of Immunoglobulin:

  • IgA
  • IgD
  • IgE
  • IgG
  • IgM
  • Pathologic Ab-Ig Protein
  • Surface Immunoglobulin

Categories for Immunoglobulin

Category of Immunoglobulin Therapy:

5

Anatomy Articles

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Disease and Condition Articles

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Related Disease and Condition Topics

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References

  1. Source: RDCRN (NCATS/NIH): rarediseasesnetwork.org/ cms/ cegir/ Learn-More/ Glossary
  2. Source: MeSH (U.S. National Library of Medicine)
  3. Source: NCI Thesaurus
  4. ibid.
  5. ibid.
  6. Source: MedLinePlus (NIH): medlineplus.gov/ viralinfections.html

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