Dendritic cells

Dendritic cells (DC) are an important antigen-presenting cell (APC), and they also can develop from monocytes. Antigens are molecules from pathogens, host cells, and allergens that may be recognized by adaptive immune cells. APCs like DCs are responsible for processing large molecules into "readable" fragments (antigens) recognized by adaptive B or T cells. However, antigens alone cannot activate T cells. They must be presented with the appropriate major histocompatiblity complex (MHC) expressed on the APC. MHC provides a checkpoint and helps immune cells distinguish between host and foreign cells.

Source: NIAID (NIH)1

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Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as Skin and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process Antigens, and present them to T-Cells, thereby stimulating Cell-Mediated Immunity. They are different from the non-hematopoietic Follicular Dendritic Cells, which have a similar morphology and immune system function, but with respect to humoral immunity (Antibody Production).2

Types

Types may include:3

Types of Dendritic Cell:

  • Conventional Dendritic Cell
  • Follicular Dendritic Cell
  • Interdigitating Dendritic Cell
  • Langerhans Cell

Categories for Dendritic cells

Category of Dendritic Cell Therapy:

  • Biological Cancer Immunotherapy
4

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References

  1. Source: NIAID (NIH): niaid.nih.gov/ topics/ immuneSystem/ Pages/ immuneCells.aspx
  2. Source: MeSH (U.S. National Library of Medicine)
  3. Source: NCI Thesaurus
  4. ibid.
  5. Source: CDC Yellow Book 2016: cdc.gov/ travel/ yellowbook/ 2016/ the-pre-travel-consultation/ scuba-diving

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